Reciprocal regulation of Ca 2+ ‐activated outward K + channels of Pyrus pyrifolia pollen by heme and carbon monoxide
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چکیده
منابع مشابه
Heme Is a Carbon Monoxide Receptor for Large-Conductance Ca -Activated K Channels
Carbon monoxide (CO) is an endogenous paracrine and autocrine gaseous messenger that regulates physiological functions in a wide variety of tissues. CO induces vasodilation by activating arterial smooth muscle large– conductance Ca -activated potassium (BKCa) channels. However, the mechanism by which CO activates BKCa channels remains unclear. Here, we tested the hypothesis that CO activates BK...
متن کاملHeme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels.
Carbon monoxide (CO) is an endogenous paracrine and autocrine gaseous messenger that regulates physiological functions in a wide variety of tissues. CO induces vasodilation by activating arterial smooth muscle large-conductance Ca2+-activated potassium (BK(Ca)) channels. However, the mechanism by which CO activates BK(Ca) channels remains unclear. Here, we tested the hypothesis that CO activate...
متن کاملRegulation of endothelial BK channels by heme oxygenase-derived carbon monoxide and caveolin-1.
A novel vasodilatory influence of endothelial cell (EC) large-conductance Ca(2+)-activated K(+) (BK) channels is present after in vivo exposure to chronic hypoxia (CH) and may exist in other pathological states. However, the mechanism of channel activation that results in altered vasoreactivity is unknown. Previously, we demonstrated that inhibition of either BK channels or heme oxygenase (HO) ...
متن کاملDifferent mechanisms underlying the stimulation of K(Ca) channels by nitric oxide and carbon monoxide.
The molecular mechanisms underlying the effects of nitric oxide (NO) and carbon monoxide (CO), individually and collectively, on large-conductance calcium-activated K(+) (K(Ca)) channels were investigated in rat vascular smooth muscle cells (SMCs). Both NO and CO increased the activity of native K(Ca) channels. Dehydrosoyasaponin-I, a specific agonist for beta subunit of K(Ca) channels, increas...
متن کاملCarbon Monoxide Neurotransmission Activated by CK2 Phosphorylation of Heme Oxygenase-2
Carbon monoxide (CO) is a putative gaseous neurotransmitter that lacks vesicular storage and must be synthesized rapidly following neuronal depolarization. We show that the biosynthetic enzyme for CO, heme oxygenase-2 (HO2), is activated during neuronal stimulation by phosphorylation by CK2 (formerly casein kinase 2). Phorbol ester treatment of hippocampal cultures results in the phosphorylatio...
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ژورنال
عنوان ژورنال: New Phytologist
سال: 2010
ISSN: 0028-646X,1469-8137
DOI: 10.1111/j.1469-8137.2010.03564.x